Anti-Artemis

Anti-Artemis
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-234A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-234A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Required for V(D)J recombination, the process by which exons encoding the... more
Product information "Anti-Artemis"
Protein function: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. [The UniProt Consortium]
Keywords: Anti-hSNM1C, Anti-ARTEMIS, Anti-DCLRE1C, EC=3.1.-.-, Anti-Protein A-SCID, Anti-SNM1 homolog C, Anti-Protein artemis, Anti-SNM1-like protein, Anti-DNA cross-link repair 1C protein
Supplier: Bethyl Laboratories
Supplier-Nr: A300-234A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan)
Immunogen: synthetic peptide. The epitope recognized by A300-234A maps to a region between residues 650 and the C-terminus (residue 692) of human DNA cross-link repair 1C (aka Artemis) using the numbering given in TrEMBL entry Q96SD1 (GeneID 64421).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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