Antikörper Anti-Akt (Ab-474) - AAT Bioquest, ABD-8B0607.50

Antikörper Treffer 1

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Name/Antigen	KLON	WIRT	TYP	ISOTYP	SPEZ. REAKT.	FORMAT	ANWENDUNG	HERSTELLER	KAT #	MENGE	PREIS

Anti-Akt (Ab-474)		Rabbit > sec. Ab	Pab	IgG	human,mouse,rat	antigen affinity purified	IHC ELISA	AAT Bioquest	ABD-8B0607.50	50 µg Buy Bulk	195 €
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis Immunogen: synthetic peptide Datenblatt ansehen Manual Kat #: ABD-8B0607.50 Menge: 50 µg Buy Bulk Preis: 195 € UniProt ID: P31749 (Protein knowledgebase) Geninformationen: GeneID 207 Antikörper-Konjugations-Kits Schlagworte: Anti-PKB, Anti-AKT1, Anti-PKB alpha, EC=2.7.11.1, Anti-RAC-PK-alpha, Anti-Protein kinase B, Anti-Proto-oncogene c-Akt, Anti-Protein kinase B alpha, Anti-RAC-alpha serine/threonine-protein kinase, antibody, antibodies, Antikörper Loading ... zurück							Weitere Produkte für dieses Protein: Antibodies Anti-AKT, Kat #: 100-401-401S Anti-Akt, Kat #: ABD-8C10531.50 Anti-Akt (Ab-124), Kat #: ABD-8B0407.50 Anti-Akt (Ab-129), Kat #: ABD-8B0609.50 Anti-Akt (Ab-246), Kat #: ABD-8B0608.50 Anti-Akt (Ab-308), Kat #: ABD-8B7005.50 Anti-Akt (Ab-326), Kat #: ABD-8B0817.50 Anti-Akt (Ab-450), Kat #: ABD-8B0406.50 Anti-Akt (Ab-473), Kat #: ABD-8B7004.50 Anti-Akt (Ab-72), Kat #: ABD-8B0610.50 more Enzymes & Proteins Akt (human recombinant) Western Ready Control, Kat #: Cay10010079-1 Akt1 unactive, Kat #: BPS-40000 Akt1, active human recombinant protein, Kat #: BPS-40003 Akt1, active, Recombinant, Human (Rac PKa, PKBa), Kat #: A1125-01L.10 siRNA AKT1 predesign siRNA, Kat #: WA-RI10214 Plasmids/Vectors Human AKT1 cDNA Clone, Kat #: WA-DC00224 Chemicals & More AKT1 Over-expression Lysate, Kat #: WA-LY10868a Peptides Akt, Substrate Peptide (Rac PKa, PKBa), Kat #: A1124-07D.1 AKT/PKBa Substrate peptide, Kat #: 000-000-260 AKT1 (Thr308) Antibody Blocking Peptide, Kat #: WA-BP10543a AKT1 Antibody (C-term) Blocking Peptide, Kat #: WA-BP7141g AKT1 Antibody (C-term) Blocking Peptide, Kat #: WA-BP7028b AKT1 Antibody (N-term G37) Blocking Peptide, Kat #: WA-BP7028c AKT1 Antibody (N-term) Blocking Peptide, Kat #: WA-BP7141h AKT1 Antibody (N-term) Blocking Peptide, Kat #: WA-BP7141a AKT1 Antibody (S124) Blocking Peptide, Kat #: WA-BP7141e AKT1 Antibody (S129) Blocking Peptide, Kat #: WA-BP7141j more Relevant Pathways: MAPK signaling pathway ErbB signaling pathway Chemokine signaling pathway mTOR signaling pathway Apoptosis VEGF signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway Jak-STAT signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Insulin signaling pathway Progesterone-mediated oocyte maturation Adipocytokine signaling pathway Carbohydrate digestion and absorption Chagas disease (American trypanosomiasis) Toxoplasmosis Tuberculosis Hepatitis C Measles Influenza A HTLV-I infection Epstein-Barr virus infection Pathways in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Products for: AKT - RAC serine/threonine-protein kinase [EC:2.7.11.1] Antibodies (260) Chemicals & More (25) Enzymes & Proteins (10) Peptides (32) Plasmids/Vectors (2) Primers (3) siRNA (3)

Datenbank vom 24.05.2013, 14:30 Uhr

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