- Search results for 135877.50
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10 products were found matching "135877.50"!
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Item number: Cay13877-50
Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with...
Keywords: | Blenoxane, bleomycin sulfate (salt) |
Application: | Apoptosis inducer |
CAS | 9041-93-4 |
MW: | 1415.6 D |
From 40.00€
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Item number: ABE-35-1358-50
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of...
Keywords: | Anti-phospho-CTNNB, Anti-phospho-CTNNB1, Anti-phospho-Beta-catenin, Anti-phospho-Catenin beta-1, beta-catenin... |
Application: | IHC, WB |
Species reactivity: | rat, mouse, human |
574.00€
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Item number: ABE-35-1357-50
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and...
Keywords: | Anti-phospho-FBXL3, Anti-phospho-FBL3A, Anti-phospho-F-box/LRR-repeat protein 3, Anti-phospho-F-box/LRR-repeat protein 3A,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
574.00€
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Item number: ABE-35-1378-50
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Protein function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1...
Keywords: | Anti-p39, Anti-AP1, Anti-JUN, Anti-Activator protein 1, Anti-Proto-oncogene c-Jun, Anti-Transcription factor Jun,... |
Application: | WB, IHC, IF |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
574.00€
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Item number: ABE-35-1857-50
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is...
Keywords: | Anti-H3FK, Anti-H3FA, Anti-H3FD, Anti-H3FF, Anti-H3FI, Anti-H3FL, Anti-H3FH, Anti-H3FJ, Anti-H3FB, Anti-Histone H3/d,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
574.00€
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Item number: Cay35817-50
8-chloro Caffeine is a derivative of the methylxanthine alkaloid caffeine (Cay-14118). It binds to adenosine receptors (apparent Ki = 30 µM). 8-chloro Caffeine (250 µM) potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. It has also been used in the synthesis of mixed lineage...
Keywords: | NSC 6277, 8-chloro-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione |
Application: | Caffeine derivative |
CAS | 4921-49-7 |
MW: | 228.6 D |
From 50.00€
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Item number: BOT-BNUM1378-50
This antibody recognizes a protein of 54 kDa, which is identified as Alpha-1 antitrypsin (AAT). AAT is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease.Primary...
Keywords: | Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) (AAT/1378), 1mg/mL, |
Application: | IHC (paraffin) (verif.), WB (verif.) |
565.00€
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Item number: 135682.50
Applications:, Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 10ug/ml, Optimal dilutions to be determined by the researcher. AA Sequence:...
Application: | IF, WB |
Host: | Mouse |
Species reactivity: | human |
699.00€
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Item number: ABD-8B1137.50
Custom conjugation services for this antibody as available (eg. labeling of Anti-AurB/C (Ab-202/175) with HRP. Available labels are AF: AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750. Proteins: HRP, Alkaline Phosphatase, Streptavidin. Tandems: APC, APC/Cy7, APC/AF750, APC/iFluor(TM) 700, APC/iFluor(TM) 750,...
Keywords: | Anti-AIK2, Anti-AURKB, Anti-STK-1, Anti-ARK-2, Anti-AIM-1, Anti-Aurora 1, EC=2.7.11.1, Anti-Aurora kinase B,... |
Application: | WB, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse |
601.00€
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Item number: ABE-35-1867-50
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to...
Keywords: | Anti-hRNF8, Anti-KIAA0646, Anti-RING finger protein 8, Anti-E3 ubiquitin-protein ligase RNF8, Anti-RING-type E3 ubiquitin... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
574.00€
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