Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A

Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0725-02Q.20 20 µl - -

3 - 19 business days*

395.00€
A0725-02Q.100 100 µl - -

3 - 19 business days*

696.00€
 
Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in... more
Product information "Anti-Acrp30 (30kD Adipocyte Complement-related Protein, Adipocyte Complement-related 30kD Protein, A"
Adiponectin, also termed AdipoQ, Acrp30, apM1 and GBP28, is an adipokine expressed exclusively in brown and white adipocytes (1). It is secreted into the blood and exists in three major forms: a low molecular weight trimer, a medium molecular weight hexamer and a high molecular weight multimer (1). Adiponectin levels are decreased in obese and insulin-resistant mice and humans (2), suggesting that this adipokine is critical to maintain insulin sensitivity. Adiponectin stimulates the phosphorylation of AMPKalpha at Thr172 and activates AMPK in skeletal muscle (3). It also stimulates glucose uptake in myocytes (3). The block of AMPK activation by a dominant-negative AMPKalpha2 isoform inhibits the effect of adiponectin on glucose uptake, indicating that adiponectin stimulates glucose uptake and increases insulin sensitivity through its action on AMPK (3). Adiponectin mutants that are not able to form oligomers larger than trimers have no effect on the AMPK pathway (4). Mutations that render adiponectin unable to form high molecular weight multimers are associated with human diabetes (4), indicating the importance of multimerization for adiponectin activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted primary antibody in 5% BSA, 1X TBS, 0.1% Tween 20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-ACRP30, Anti-Gelatin-binding protein, Anti-Adipocyte complement-related 30 kDa protein, Anti-30 kDa adipocyte complement-related protein, Anti-Adipose most abundant gene transcript 1 protein
Supplier: United States Biological
Supplier-Nr: A0725-02Q

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 10g127(C45B10)
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide corresponding to human Acrp30.
Format: Supernatant

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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