Anti-ATR

Anti-ATR
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-A30 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... more
Product information "Anti-ATR"
Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. [The UniProt Consortium]
Keywords: Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia telangiectasia and Rad3-related protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-A30

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat, monkey, dog, fish, Xenopus
Immunogen: synthetic peptide corresponding to an internal region of human ATR protein
MW: 301 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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