Anti-AKT3 Allophycocyanin Conjugated, clone 25F6.F6.D8

Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-326-E75 50 µg - -

6 - 10 business days*

713.00€
 
Anti-AKT3 antibody is directed against human AKT3. The antibody detects both unphosphorylated and... more
Product information "Anti-AKT3 Allophycocyanin Conjugated, clone 25F6.F6.D8"
Anti-AKT3 antibody is directed against human AKT3. The antibody detects both unphosphorylated and phosphorylated forms of the protein. Anti-AKT3 antibody was purified from ascites by Protein A chromatography. Cross reactivity with AKT3 from other species has not been determined, however, the sequence of the immunogen shows 100% identity to human, mouse, and rat, therefore, cross reactivity is expected. Cross-reactivity with AKT2 and AKT has not been determined. Protein function: AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. [The UniProt Consortium]
Keywords: Anti-PKBG, Anti-AKT3, Anti-STK-2, Anti-PKB gamma, EC=2.7.11.1, Anti-RAC-PK-gamma, Anti-Protein kinase Akt-3, Anti-Protein kinase B gamma, Anti-RAC-gamma serine/threonine-protein kinase
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-326-E75

Properties

Application: ELISA, FC, IHC, IFM, WB
Antibody Type: Monoclonal
Clone: 25F6.F6.D8
Conjugate: APC
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: synthetic peptide corresponding to internal residues of human AKT3 protein.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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