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ART NR.: A300-501A (100 µl / 100 µg)

Hersteller: Bethyl


Anwendungen: WB

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, swine, mouse, rat (expected: rabbit, orangutan, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, chinese hamster, thirteen-lined ground squirrel)

Immunogen: synthetic peptide. The epitope recognized by A300-501A maps to a region between residue 75 and the C-terminus (residue 118) of human eukaryotic translation initiation factor 4E binding protein 1 using the numbering given in entry NP_004086.1 (GeneID 1978)

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q13541 | Suche mit UniProt ID

KEGG ID: K07205 | Suche mit KEGG ID

Schlagworte: Anti-eIF-4EBP-1, Anti-PHAS-I, Anti-4E-BP1, Anti-PHAS


100 µl (100 µg)

356 €

In Warenkorb aufnehmen

Bemerkungen: Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed. 4EBP1 is also called eIF4E-binding protein, phosphorylated heat-and-acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1, BP-1, and MGC4316.


4EBP1 Antibody

Rabbit anti-4EBP1 Antibody, Affinity Purified
4EBP1 Antibody4EBP1 Antibody
4EBP1 Antibody4EBP1 Antibody

Gene and Protein Information


Steiner JL et al., Sepsis attenuates the anabolic response to skeletal muscle contraction. Shock. 2014 Nov 24. WB
PubMed: 25423127
Koehler JA et al., Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis. Diabetes. 2014 Oct 2. pii: DB_140883. WB
PubMed: 25277394
Steiner JL et al., Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction. J Appl Physiol (1985). 2014 Sep 25:jap.00180.2014. WB
PubMed: 25257868
Laufenberg LJ et al., Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle. Amino Acids. 2014 Sep 14. WB
PubMed: 25218136
Steiner JL et al., Disruption of Genes Encoding eIF4E Binding Proteins-1 And -2 Does Not Alter Basal or Sepsis-Induced Changes in Skeletal Muscle Protein Synthesis in Male or Female Mice PLoS One. 2014 Jun 19;9(6):e99582.  WB
PubMed: 24945486
She P et al., General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-Chain Amino Acid Deficiency in Mice. J Biol Chem. 2013 Sep 9. WB
PubMed: 24019515
PubMed: 23926289
Lang CH et al., Chronic alpha-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy. Am J Physiol Endocrinol Metab. 2013 Aug;305(3):E416-28. WB
PubMed: 23757407
Kobayashi M et al., Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication. J Virol. 2012 Oct;86(19):10686-94. WB
PubMed: 22837200
Lang SM et al., Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice. PLoS One. 2012;7(6):e38910. WB
PubMed: 22745686
Winter JN et al., Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol. 2010 Aug;299(2):C335-44. WB
PubMed: 20427710
Konsavage W et al., Hyperoxia inhibits protein synthesis and increases eIF2? phosphorylation in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L678-86. WB
PubMed: 20139179
Wilson FA et al., Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr. 2009 Oct;139(10):1873-80. WB
PubMed: 19692527
Baum JI et al., Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E410-5. WB
PubMed: 19509187
Tyler WA et al., Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci. 2009 May 13;29(19):6367-78. WB
PubMed: 19439614
Norton LE et al., The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J Nutr. 2009 Jun;139(6):1103-9. WB
PubMed: 19403715
Hwee DT et al., Age-related deficit in load-induced skeletal muscle growth. J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):618-28.
PubMed: 19351696
Vasseur S et al., DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1111-6. WB
PubMed: 19144925
Pruznak AM et al., Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr. 2008 Oct;138(10):1887-94. WB
PubMed: 18806097
Pruznak AM et al., Skeletal and cardiac myopathy in HIV-1 transgenic rats. Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E964-73. WB
PubMed: 18713959
Wilson FA et al., Fed levels of amino acids are required for the somatotropin-induced increase in muscle protein synthesis. Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E876-83. WB
PubMed: 18682537
Wilson FA et al., Stimulation of muscle protein synthesis by somatotropin in pigs is independent of the somatotropin-induced increase in circulating insulin. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E187-94. WB
PubMed: 18460595
Walsh D et al., Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells. Mol Cell Biol. 2008 Apr;28(8):2648-58. WB
PubMed: 18250159
Kimball SR et al., Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem. 2008 Feb 8;283(6):3465-75. WB
PubMed: 18070882
Suryawan A et al., Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1597-605. WB
PubMed: 17878222
Orellana RA et al., Amino acids augment muscle protein synthesis in neonatal pigs during acute endotoxemia by stimulating mTOR-dependent translation initiation. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1416-25. WB
PubMed: 17848637
Lamouille S et al., Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007 Jul 30;178(3):437-51. WB
PubMed: 17646396
Jeyapalan AS et al., Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process. Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E595-603. WB
PubMed: 17551002
Shaheen HH et al., Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8845-50. WB
PubMed: 17502605
Lang CH et al., Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1497-506. WB, IP
PubMed: 17264221
Anthony TG et al., Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male rats. J Nutr. 2007 Feb;137(2):357-62. WB
PubMed: 17237311
Wang H et al., Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem. 2006 Dec 22;281(51):39128-34. WB
PubMed: 17074751
Orellana RA et al., Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E629-36. WB
PubMed: 17047163
Vary TC et al., Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R778-87. ELISA
PubMed: 16946086
Vary TC et al., Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. J Nutr. 2006 Sep;136(9):2284-90. WB
PubMed: 16920842
Arvisais EW et al., AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha. J Biol Chem. 2006 Sep 15;281(37):26904-13. WB
PubMed: 16816403
Williamson DL et al., Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E80-9. WB
PubMed: 16760336
Caso G et al., The increase in human muscle protein synthesis induced by food intake is similar when assessed with the constant infusion and flooding techniques. J Nutr. 2006 Jun;136(6):1504-10. WB
PubMed: 16702312
Lang CH., Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E666-74. WB
PubMed: 16684854
Lynch CJ et al., Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E621-30. WB
PubMed: 16638821
Escobar J et al., Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs. Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E612-21. WB
PubMed: 16278252
Vary TC., IGF-I stimulates protein synthesis in skeletal muscle through multiple signaling pathways during sepsis. Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R313-21. WB, IP
PubMed: 16150839
Krawiec BJ et al., Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E969-80. WB
PubMed: 16046454
Crozier SJ et al., Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1242-50. WB
PubMed: 15894572
Hong-Brown LQ et al., Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E382-90. WB
PubMed: 15827064
Williamson DL et al., Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E95-104. WB
PubMed: 15701678
Dufner DA et al., Using 2H2O to study the influence of feeding on protein synthesis: effect of isotope equilibration in vivo vs. in cell culture. Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1277-83. WB
PubMed: 15671077
Escobar J et al., Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. Am J Physiol Endocrinol Metab. 2005 May;288(5):E914-21. WB
PubMed: 15644455
Reiter AK et al., Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab. 2005 May;288(5):E980-8. WB
PubMed: 15613684
Kubica N et al., Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem. 2005 Mar 4;280(9):7570-80. WB
PubMed: 15591312
Kimball SR et al., Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. J Biol Chem. 2004 Dec 24;279(52):54103-9. WB
PubMed: 15494402
Anthony TG et al., Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004 Aug 27;279(35):36553-61. WB
PubMed: 15213227
Lang CH et al., Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E721-30. WB
PubMed: 15186995
Kimball SR et al., A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1. Anal Biochem. 2004 Feb 15;325(2):364-8. WB
PubMed: 14751272
Lang CH et al., Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab. 2003 Dec;285(6):E1205-15. WB
PubMed: 12944322

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