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Anti-AMPK alpha 2

ART NR.: A300-508A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, rat, bovine (expected: mouse, rabbit, guinea pig, swine, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, naked mole rat, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A300-508A maps to a region between residues 350 and 400 of human 5'-AMP-activated Protein Kinase, catalytic Alpha-2 chain using the numbering given in entry AAH69823.1 (GeneID 5563).

Lagerung: +4°C

Versand: +4°C

UniProt ID: P54646 | Suche mit UniProt ID

KEGG ID: K07198 | Suche mit KEGG ID

Schlagworte: EC=2.7.11.1, Anti-PRKAA2, Anti-protein kinase, Anti-AMP-activated, Anti-alpha 2 catalytic subunit.

A300-508A

100 µl (100 µg)

385 €

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Bemerkungen: AMP-activated protein kinase (AMPK) is a heterotrimeric protein made up of a catalytic alpha subunit, and a regulatory beta and gamma subunit. There are two distinct genes for the alpha subunit, alpha1 and alpha2. AMPK alpha 2 is the serine/threonine kinase catalytic subunit of the AMPK. AMPK is responsible for regulating fatty acid and cholesterol synthesis. AMPK is activated in response to a wide variety of metabolic stresses and switches off anabolic pathways when ATP levels are depleted. AMPK alpha 2 is also known as 5-AMP-activated protein kinase catalytic subunit alpha-2, AMPK alpha-2 chain, PRKAA, PRKAA2, AMPK, and AMPK2,

Spezifikationen

AMPK alpha 2 Antibody

Rabbit anti-AMPK alpha 2 Antibody, Affinity Purified
AMPK alpha 2 Antibody

Gene and Protein Information

Citations

Hardman SE, effects of age and muscle contraction on AMPK activity and heterotrimer composition. Exp Gerontol. 2014 Apr 17. pii: S0531-5565(14)00128-4.
PubMed: 24747582
Lin D, Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: The role of AMP-activated protein kinase α2 subunit. Mol Nutr Food Res. 2014 May;58(5):1005-15.
PubMed: 24449471
Harmel E, AMPK in the small intestine in normal and pathophysiological conditions Endocrinology. 2014 Jan 1:en20131750. WB
PubMed: 24424053
Yu JW, Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPKsignaling pathway. Int J Infect Dis. 2013 Jul;17(7):e539-45. IP
PubMed: 23510538
Scheele C et al., Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6. PLoS One. 2012;7(6):e39657. IP
PubMed: 22761857
Wang S et al., AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J Biol Chem. 2010 Jun 25;285(26):19976-85. WB
PubMed: 20392689
Bendayan M et al., Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy. J Histochem Cytochem. 2009 Oct;57(10):963-71. WB
PubMed: 19581628
Hou X et al., SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008 Jul 18;283(29):20015-26. WB
PubMed: 18482975
Qin S et al., Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1274-81. WB
PubMed: 18326758
Cammisotto PG et al., Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. WB, ICC
PubMed: 18256313
Qin S et al., alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments. J Biol Chem. 2008 Mar 14;283(11):6744-51. WB
PubMed: 18195011
Zang M et al., Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006 Aug;55(8):2180-91. WB
PubMed: 16873680
Doi M et al., Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr. 2005 Sep;135(9):2103-8. IP
PubMed: 16140883
Rubin LJ et al., Metabolic activation of AMP kinase in vascular smooth muscle. J Appl Physiol. 2005 Jan;98(1):296-306. WB, IP
PubMed: 15377643
Zang M et al., AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 2004 Nov 12;279(46):47898-905. WB
PubMed: 15371448
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