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Anti-Raptor

ART NR.: A300-506A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, rat, mouse (expected: X. tropicalis, bovine, horse, rabbit, swine, duckbill platypus, chinese hamster, gray short-tailed opossum)

Immunogen: synthetic peptide. The epitope recognized by A300-506A maps to a region between residues 975 and 1025 of human Regulatory associated protein of mTOR using the numbering given in entry AAM09075.1 (GeneID 57521)

Lagerung: +4°C

Versand: +4°C

UniProt ID: Q8N122 | Suche mit UniProt ID

KEGG ID: K07204 | Suche mit KEGG ID

Schlagworte: Anti-Raptor, Anti-regulatory associated protein of mTOR, Anti-p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, Anti-KIAA1303.

A300-506A

100 µl (100 µg)

393 €

In Warenkorb aufnehmen


Bemerkungen: Raptor (regulatory-associated protein of mTOR) is part of the rapamycin sensitive mTORC1 complex which includes mTOR, and mLst8/GbetaL. S6K and 4EBP1 are substrates of mTORC1 kinase activity. Raptor is required for mTOR´s ability to phosphorylate 4E-BP1 and physically interacts with 4EBP1 to act as a potential scaffold that bridges mTOR and 4EBP1 or S6K. The mTORC1 complex integrates cell signals to promote cell growth in response to growth factors. Raptor is also known as P150 target of rapamycin (TOR)-scaffold protein, and KIAA1303.

Spezifikationen

Raptor Antibody

Rabbit anti-Raptor Antibody, Affinity Purified
Raptor Antibody

Gene and Protein Information

Citations

Dan HC, Akt-Dependent Activation of mTORC1 Involves Phosphorylation of mTOR by IKKalpha. J Biol Chem. 2014 Jul 2. pii: jbc.M114.554881.
PubMed: 24990947
Koo J, Maintaining glycogen synthase kinase-3 activity is critical for mTOR kinase inhibitors to inhibit cancer cell growth. Cancer Res. 2014 Mar 13.
PubMed: 24626091
Moschella PC, mTOR Complex 2 mediates Akt Phosphorylation that Requires PKC? in Adult Cardiac Muscle Cells. Cell Signal. 2013 May 11;25(9):1904-1912. WB
PubMed: 23673367
Rajan MR, Phosphorylation of IRS1 at Serine 307 in Response to Insulin in Human Adipocytes Is Not Likely to be Catalyzed by p70 Ribosomal S6 Kinase. PLoS One. 2013;8(4):e59725. WB
PubMed: 23565163
Carter HN et al., Contractile activity-induced mitochondrial biogenesis and mTORC1. Am J Physiol Cell Physiol. 2012 Sep;303(5):C540-7. WB
PubMed: 22700793
Gulhati P et al., mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res. 2011 May 1;71(9):3246-56. WB, IHC-P
PubMed: 21430067
Liu L et al., Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem. 2010 Dec 3;285(49):38362-73. WB
PubMed: 20937815
Kantidakis T et al., mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11823-8. WB
PubMed: 20543138
Siegel N et al., Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet. 2010 Sep 1;19(17):3320-31. WB
PubMed: 20542987
Gulhati P et al., Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. Clin Cancer Res. 2009 Dec 1;15(23):7207-16. WB, IHC-P
PubMed: 19934294
Shu L et al., The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts. Mol Cell Biol. 2009 Sep;29(17):4691-700. WB
PubMed: 19564418
Sato T et al., Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem. 2009 May 8;284(19):12783-91. WB, IP
PubMed: 19299511
Beevers CS et al., Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res. 2009 Feb 1;69(3):1000-8. WB
PubMed: 19176385
Mills JR et al., mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. WB
PubMed: 18664580
Dan HC et al., Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008 Jun 1;22(11):1490-500. WB
PubMed: 18519641
Hagan GN et al., A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 2008 Jul;28(13):4215-26. WB, IP
PubMed: 18426911
Vary TC et al., Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts. J Nutr. 2007 Aug;137(8):1857-62. WB
PubMed: 17634255
Dan HC et al., Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer Res. 2007 Jul 1;67(13):6263-9. WB
PubMed: 17616684
Ballou LM et al., Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. WB
PubMed: 17562705
Urano J et al., Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3514-9. WB
PubMed: 17360675
Takahara T et al., Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem. 2006 Sep 29;281(39):28605-14. WB
PubMed: 16870609
Williamson DL et al., Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol. 2006 Jun 1;573(Pt 2):497-510. WB
PubMed: 16543272
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