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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-A41 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
This affinity purified antibody is directed against human SMAD4 protein. The product was affinity... more
Product information "Anti-SMAD4"
This affinity purified antibody is directed against human SMAD4 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with SMAD4 protein from human, mouse and Xenopus based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. Protein function: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14- 3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]
Keywords: | Anti-DPC4, Anti-SMAD4, Anti-Smad4, Anti-hSMAD4, Anti-SMAD 4, Anti-MAD homolog 4, Anti-SMAD family member 4, Anti-Mothers against DPP homolog 4, Anti-Deletion target in pancreatic carcinoma 4, Anti-Mothers against decapentaplegic homolog 4 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-A41 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, Xenopus |
Immunogen: | synthetic peptide corresponding to a region near the carboxy terminus of human SMAD4 protein. |
Format: | Purified |
Database Information
KEGG ID : | K04501 | Matching products |
UniProt ID : | Q13485 | Matching products |
Gene ID | GeneID 4089 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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