Anti-SMAD4

Anti-SMAD4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-A41 100 µg - -

6 - 10 business days*

684.00€
 
This affinity purified antibody is directed against human SMAD4 protein. The product was affinity... more
Product information "Anti-SMAD4"
This affinity purified antibody is directed against human SMAD4 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.  A BLAST analysis was used to suggest cross-reactivity with SMAD4 protein from human, mouse and Xenopus based on 100% homology with the immunizing sequence.  Reactivity against homologues from other sources is not known. Protein function: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14- 3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]
Keywords: Anti-DPC4, Anti-SMAD4, Anti-Smad4, Anti-hSMAD4, Anti-SMAD 4, Anti-MAD homolog 4, Anti-SMAD family member 4, Anti-Mothers against DPP homolog 4, Anti-Deletion target in pancreatic carcinoma 4, Anti-Mothers against decapentaplegic homolog 4
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-A41

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, Xenopus
Immunogen: synthetic peptide corresponding to a region near the carboxy terminus of human SMAD4 protein.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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