Anti-phospho-c-Met proto-oncogene tyrosine kinase (Tyr1349/1356)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-989S 25 µl - -

6 - 10 business days*

180.00€
600-401-989 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix... more
Product information "Anti-phospho-c-Met proto-oncogene tyrosine kinase (Tyr1349/1356)"
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. [The UniProt Consortium]
Keywords: Anti-phospho-MET, Anti-phospho-SF receptor, EC=2.7.10.1, Anti-phospho-HGF receptor, Anti-phospho-HGF/SF receptor, Anti-phospho-Proto-oncogene c-Met, Anti-phospho-Scatter factor receptor, Anti-phospho-Tyrosine-protein kinase Met
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-989

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide corresponding to residues surrounding Y1349 and Y1356 of human c-Met
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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