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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-935 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
Protein function: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for... more
Product information "Anti-phospho-ECT2 (Thr790) (Epithelial Cell Transforming Sequence 2)"
Protein function: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)- induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. [The UniProt Consortium]
Keywords: | Anti-phospho-ECT2, Anti-phospho-Protein ECT2, Anti-phospho-Epithelial cell-transforming sequence 2 oncogene |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-935 |
Properties
Application: | ELISA, IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | synthetic peptide corresponding to amino acids 785-795 of human ECT2 protein |
MW: | 101 |
Format: | Affinity Purified |
Database Information
KEGG ID : | K20704 | Matching products |
UniProt ID : | Q9H8V3 | Matching products |
Gene ID | GeneID 1894 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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