Anti-phospho-Smad3 (Ser423, Ser425)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-919S 25 µl - -

6 - 10 business days*

180.00€
600-401-919 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and... more
Product information "Anti-phospho-Smad3 (Ser423, Ser425)"
Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]
Keywords: Anti-phospho-Mad3, Anti-phospho-Smad3, Anti-phospho-SMAD3, Anti-phospho-MADH3, Anti-phospho-hMAD-3, Anti-phospho-hSMAD3, Anti-phospho-JV15-2, Anti-phospho-SMAD 3, Anti-phospho-MAD homolog 3, Anti-phospho-SMAD family member 3
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-919

Properties

Application: ELISA, FC, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: Xenopus laevis, Xenopus tropicalis, zebrafish, rat, mouse, swine, bovine, chi)
Immunogen: synthetic peptide corresponding to amino acids 417-425 of human SMAD3 protein
MW: 48 kD

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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