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Anti-phospho-Smad3 (Ser423, Ser425)

ART NR.: 600-401-919S (25 µl)
600-401-919 (100 µg)

Hersteller: Rockland

Datenblatt

Anwendungen: ELISA, WB, IHC

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: Xenopus laevis, Xenopus tropicalis, zebrafish, rat, mouse, swine, bovine, chi)

Immunogen: synthetic peptide corresponding to amino acids 417-425 of human SMAD3 protein

UniProt ID: P84022
Suche mit UniProt ID

Geninformationen: GeneID 4088

Schlagworte: Anti-phospho-Mad3, Anti-phospho-Smad3, Anti-phospho-SMAD3, Anti-phospho-MADH3, Anti-phospho-hMAD-3, Anti-phospho-hSMAD3, Anti-phospho-JV15-2, Anti-phospho-SMAD 3, Anti-phospho-MAD homolog 3, Anti-phospho-SMAD family member 3

600-401-919S

25 µl

114 €

102 €
600-401-919

100 µg

371 €

333 €
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Bemerkungen: Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]

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