Anti-BORIS

Anti-BORIS
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-907 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Testis-specific DNA binding protein responsible for insulator function, nuclear... more
Product information "Anti-BORIS"
Protein function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. [The UniProt Consortium]
Keywords: Anti-CT27, Anti-CTCF paralog, Anti-CTCF-like protein, Anti-CCCTC-binding factor, Anti-Cancer/testis antigen 27, Anti-Zinc finger protein CTCF-T, Anti-Transcriptional repressor CTCFL, Anti-Brother of the regulator of imprinted sites
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-907

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: chimpanzee)
Immunogen: synthetic peptide corresponding to amino acids 9-26 of human BORIS protein
MW: 75 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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