Anti-Mre11

Anti-Mre11
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-896 100 µg - -

6 - 10 business days*

684.00€
 
Protein function: Component of the MRN complex, which plays a central role in double-strand break... more
Product information "Anti-Mre11"
Protein function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. [The UniProt Consortium]
Keywords: Anti-Mre11, Anti-Mre11a, Anti-MmMRE11A, Anti-MRE11 homolog A, Anti-MRE11 homolog 1, Anti-Meiotic recombination 11 homolog A, Anti-Meiotic recombination 11 homolog 1, Anti-Double-strand break repair protein MRE11A
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-896

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse
Immunogen: recombinant mouse Mre11 protein (aa 68-706)
MW: 80 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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