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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-895 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
Protein function: Serine/threonine-protein kinase involved in cell polarity and microtubule... more
Product information "Anti-phospho-MARK2 (Thr 595)"
Protein function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule- dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. [The UniProt Consortium]
Keywords: | Anti-phospho-EMK1, Anti-phospho-MARK2, Anti-phospho-EMK-1, Anti-phospho-Par1b, Anti-phospho-Par-1b, EC=2.7.11.1, Anti-phospho-PAR1 homolog, EC=2.7.11.26, Anti-phospho-PAR1 homolog b, Anti-phospho-ELKL motif kinase 1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-895 |
Properties
Application: | ELISA, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: dog, bovine, mouse, rat) |
Immunogen: | synthetic peptide corresponding to amino acids 591-603 of human MARK2 isoform a |
MW: | 83.00 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08798 | Matching products |
UniProt ID : | Q7KZI7 | Matching products |
Gene ID | GeneID 2011 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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