Anti-BTBD12 (IHC)

Anti-BTBD12 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00643-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00643 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Regulatory subunit that interacts with and increases the activity of different... more
Product information "Anti-BTBD12 (IHC)"
Protein function: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure- specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81- EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. [The UniProt Consortium]
Keywords: Anti-SLX4, Anti-BTBD12, Anti-BTB/POZ domain-containing protein 12, Anti-Structure-specific endonuclease subunit SLX4
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00643

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: gorilla, chimpanzee)
Immunogen: The epitope recognized by IHC-00643 maps to a region between residue 1784 to 1834 of human BTB (POZ) domain containing 12 using the numbering given in entry NP_115820.2 (GeneID 84464).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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