Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro. however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Immunogen: synthetic peptide. The epitope recognized by IHC-00638 maps to a region between residue 550 and 600 of human microtubule associated serine/threonine kinase-like using the numbering given in entry NP_116233.2 (GeneID 84930).
Datenblatt ansehen
Kat #: IHC-00638
Menge: 100 µlBuy Bulk
Preis: 399 €
UniProt ID: Q96GX5 (Protein knowledgebase)
Geninformationen: GeneID 84930
Antikörper-Konjugations-Kits
Schlagworte:
Anti-GW, Anti-GWL, Anti-hGWL, Anti-MASTL, EC=2.7.11.1, Anti-MAST-L, Anti-Serine/threonine-protein kinase greatwall, Anti-Microtubule-associated serine/threonine-protein kinase-like, antibody, antibodies, Antikörper Loading ...
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| Weitere Produkte für dieses Protein:Antibodies
- Anti-MASTL, Kat #: ABD-8C11491.50
- Anti-MASTL, Kat #: WA-AM1911b.20
- Anti-MASTL, Kat #: WA-AM1911b
- Anti-MASTL, Kat #: A302-190A
- Anti-MASTL, Kat #: WA-AP7147d.20
- Anti-MASTL, Kat #: WA-AP7147d
- Anti-MASTL (ascites), Kat #: WA-AM1911a
- Anti-MASTL (ascites), Kat #: WA-AM1911a.20
- Anti-MASTL (Microtubule Associated Serine/threonine Protein Kinase-like, FLJ14813, RP11-85G18.2, THC2), Kat #: M2415-60.100
- Anti-MASTL (monoclonal) (M01), Kat #: WA-AT2807a
siRNA
Primers
Products for: E2.7.11.1 - non-specific serine/threonine protein kinase [EC:2.7.11.1]
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