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Anti-MASTL (IHC)

ART NR.: IHC-00638 (100 µl)

Hersteller: Bethyl

Datenblatt

Anwendungen: IHC, IHC-​IF

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human

Immunogen: synthetic peptide. The epitope recognized by IHC-00638 maps to a region between residue 550 and 600 of human microtubule associated serine/threonine kinase-like using the numbering given in entry NP_116233.2 (GeneID 84930).

UniProt ID: Q96GX5
Suche mit UniProt ID

Geninformationen: GeneID 84930

Schlagworte: Anti-GW, Anti-GWL, Anti-hGWL, Anti-MASTL, EC=2.7.11.1, Anti-MAST-L, Anti-Serine/threonine-protein kinase greatwall, Anti-Microtubule-associated serine/threonine-protein kinase-like

100 µl

401 €

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Bemerkungen: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro. however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Spezifikationen

bethyl_datasheet_parse.php?nr=IHC-00638&ak=1
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