Anti-eIF3J/EIF3S1 (IHC)

Anti-eIF3J/EIF3S1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00617-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00617 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex,... more
Product information "Anti-eIF3J/EIF3S1 (IHC)"
Protein function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [The UniProt Consortium]
Keywords: Anti-eIF3j, Anti-PRO0391, Anti-eIF3 p35, Anti-eIF-3-alpha, Anti-Eukaryotic translation initiation factor 3 subunit J, Anti-Eukaryotic translation initiation factor 3 subunit 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00617

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, dog, horse, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, naked mole rat, chinese hamster)
Immunogen: The epitope recognized by IHC-00617 maps to a region between residue 208 and 258 of human eukaryotic translation initiation factor 3, subunit J (eukaryotic translation initiation factor 3, subunit 1) using the numbering given in entry NP_003749.2 (GeneID
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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