Anti-BMI1 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00606-T	10 µl (2500 ng)		-		2 - 8 business days*		164.00€
IHC-00606	100 µl (25 µg)		-		2 - 8 business days*		623.00€

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Protein function: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex... more

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Product information "Anti-BMI1 (IHC)"

Protein function: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249). [The UniProt Consortium]

Keywords:	Anti-BMI1, Anti-PCGF4, Anti-RING finger protein 51, Anti-Polycomb complex protein BMI-1, Anti-Polycomb group RING finger protein 4
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00606

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, X. tropicalis, chicken, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, cat, orangutan, monkey, gorilla)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00606 maps to a region between residue 276 and 326 of human B lymphoma Mo-MLV insertion region 1 homolog using the numbering given in entry NP_005171.4 (GeneID 648).
Format:	Antigen Affinity Purified