Anti-Diaphanous 1 (IHC)

Anti-Diaphanous 1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00571-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00571 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for... more
Product information "Anti-Diaphanous 1 (IHC)"
Protein function: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). [The UniProt Consortium]
Keywords: Anti-DRF1, Anti-DIAP1, Anti-DIAPH1, Anti-Diaphanous-related formin-1, Anti-Protein diaphanous homolog 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00571

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, gorilla, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00571 maps to a region between residues 1200 and the C-terminus (residue 1248) of human Diaphanous Homolog 1 using the numbering given in entry NP_005210.1 (GeneID 1729).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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