Anti-BIG2/ARFGEF2 (IHC)

Anti-BIG2/ARFGEF2 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00545-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00545 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on... more
Product information "Anti-BIG2/ARFGEF2 (IHC)"
Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles, the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. [The UniProt Consortium]
Keywords: Anti-ARFGEF2, Anti-ARFGEP2, Anti-Brefeldin A-inhibited GEP 2, Anti-Brefeldin A-inhibited guanine nucleotide-exchange protein 2, Anti-ADP-ribosylation factor guanine nucleotide-exchange factor 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00545

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, monkey, gorilla, chimpanzee, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by IHC-00545 maps to a region between residue 300 and 350 of human brefeldin A-inhibited 2 (ADP-ribosylation factor guanine nucleotide-exchange factor 2) using the numbering given in entry NP_006411.1 (GeneID 10564).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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