Anti-Notch2 (IHC)

Anti-Notch2 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00539-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00539 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1... more
Product information "Anti-Notch2 (IHC)"
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737). [The UniProt Consortium]
Keywords: Anti-NOTCH2, Anti-NOTCH-2, Anti-neurogenic locus notch homolog protein 2, Anti-AGS2.
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00539

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: monkey, gorilla, red-chested mustached tamarin, northern white-cheeked gibbon, kloss's gibbon, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by IHC-00539 maps to a region between residue 2421 and 2471 of human neurogenic locus notch homolog protein 2 using the numbering given in entry NP_077719.2 (GeneID 4853).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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