Anti-Notch1 (IHC)

Anti-Notch1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00538-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00538 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1... more
Product information "Anti-Notch1 (IHC)"
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). [The UniProt Consortium]
Keywords: Anti-TAN1, Anti-NOTCH1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00538

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, crab-eating macaque, white-tufted-ear marmoset)
Immunogen: synthetic peptide. The epitope recognized by IHC-00538 maps to a region between residue 2505 and 2555 of human Notch ortholog 1, translocation-associated using the numbering given in entry NP_060087.3 (GeneID 4851).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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