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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00526-T | 10 µl (1 µg) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00526 | 100 µl (10 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Involved in both DNA replication and cell cycle control (PubMed:27906959).... more
Product information "Anti-C1orf55 (IHC)"
Protein function: Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S- phase progression (PubMed:27906959). [The UniProt Consortium]
Keywords: | Anti-SDE2, Anti-C1orf55, Anti-Replication stress response regulator SDE2 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00526 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: monkey, gorilla, chimpanzee, northern white-cheeked gibbon, crab-eating macaque) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00526 maps to a region between residue 350 and 400 of human chromosome 1 open reading frame 55 using the numbering given in entry NP_689821.3 (GeneID 163859). |
Format: | Antigen Affinity Purified |
Database Information
UniProt ID : | Q6IQ49 | Matching products |
Gene ID | GeneID 163859 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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