Anti-USP33 (IHC)

Anti-USP33 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00508-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00508 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Deubiquitinating enzyme involved in various processes such as centrosome... more
Product information "Anti-USP33 (IHC)"
Protein function: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta- arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. [The UniProt Consortium]
Keywords: Anti-USP33, Anti-hVDU1, Anti-KIAA1097, EC=3.4.19.12, Anti-Ubiquitin thioesterase 33, Anti-Deubiquitinating enzyme 33, Anti-Ubiquitin carboxyl-terminal hydrolase 33, Anti-Ubiquitin-specific-processing protease 33
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00508

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00508 maps to a region between residue 900 and the C-terminus (residue 942) of human Ubiquitin Specific Peptidase 33 using the numbering given in entry NP_055832.3 (GeneID 23032).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-USP33 (IHC)"
Write a review
or to review a product.
Viewed