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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00507-T | 10 µl (1 µg) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00507 | 100 µl (10 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates... more
Product information "Anti-USP15 (IHC)"
Protein function: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. [The UniProt Consortium]
Keywords: | Anti-Unph4, Anti-USP15, Anti-Unph-2, Anti-KIAA0529, EC=3.4.19.12, Anti-Ubiquitin thioesterase 15, Anti-Deubiquitinating enzyme 15, Anti-Ubiquitin carboxyl-terminal hydrolase 15, Anti-Ubiquitin-specific-processing protease 15 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00507 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: X. tropicalis, chicken, turkey, bovine, dog, horse, rabbit, pig, panda, orangutan, monkey, gorilla, chimpanzee) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00507 maps to a region between residue 960 and the C-terminus of human Ubiquitin Specific Peptidase 15 using the numbering given in entry AAD41086.1 (GeneID 9958). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K21343 | Matching products |
UniProt ID : | Q9Y4E8 | Matching products |
Gene ID | GeneID 9958 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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