Anti-DHX33 (IHC)

Anti-DHX33 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00503-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00503 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis... more
Product information "Anti-DHX33 (IHC)"
Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF- kappa-B signaling pathways. [The UniProt Consortium]
Keywords: Anti-DDX33, EC=3.6.4.13, Anti-DEAH box protein 33, Anti-ATP-dependent RNA helicase DHX33
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00503

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: horse, orangutan, monkey, gorilla, chimpanzee, hirteen-lined ground squirrel, small-eared galago, african elephant)
Immunogen: synthetic peptide. The epitope recognized by IHC-00503 maps to a region between residue 1 and 50 of human DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 using the numbering given in entry NP_064547.2 (GeneID 56919).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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