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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00503-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00503 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis... more
Product information "Anti-DHX33 (IHC)"
Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF- kappa-B signaling pathways. [The UniProt Consortium]
Keywords: | Anti-DDX33, EC=3.6.4.13, Anti-DEAH box protein 33, Anti-ATP-dependent RNA helicase DHX33 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00503 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: horse, orangutan, monkey, gorilla, chimpanzee, hirteen-lined ground squirrel, small-eared galago, african elephant) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00503 maps to a region between residue 1 and 50 of human DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 using the numbering given in entry NP_064547.2 (GeneID 56919). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K17820 | Matching products |
UniProt ID : | Q9H6R0 | Matching products |
Gene ID | GeneID 56919 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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