Anti-BIG1/ARFGEF1 (IHC)

Anti-BIG1/ARFGEF1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00499-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00499 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation... more
Product information "Anti-BIG1/ARFGEF1 (IHC)"
Protein function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure, the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. [The UniProt Consortium]
Keywords: Anti-ARFGEF1, Anti-ARFGEP1, Anti-p200 ARF-GEP1, Anti-Brefeldin A-inhibited GEP 1, Anti-p200 ARF guanine nucleotide exchange factor, Anti-Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00499

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, bovine, dog, pig, panda, orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00499 maps to a region between residue 1800 and the C-terminus (residue 1849) of human brefeldin A-inhibited guanine nucleotide-exchange protein 1 using the numbering given in entry NP_006412.2 (GeneID 10565).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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