Anti-G9A/EHMT2 (IHC)

Anti-G9A/EHMT2 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00489-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00489 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of... more
Product information "Anti-G9A/EHMT2 (IHC)"
Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. [The UniProt Consortium]
Keywords: Anti-BAT8, Anti-EHMT2, EC=2.1.1.-, EC=2.1.1.43, Anti-Protein G9a, Anti-H3-K9-HMTase 3, Anti-HLA-B-associated transcript 8, Anti-Lysine N-methyltransferase 1C, Anti-Histone H3-K9 methyltransferase 3, Anti-Histone-lysine N-methyltransferase EHMT2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00489

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: rabbit, orangutan, monkey, gorilla, small-eared galago)
Immunogen: synthetic peptide. The epitope recognized by IHC-00489 maps to a region between residue 1160 and the C-terminus (residue 1210) of human G9A (Euchromatic Histone-Lysine N-methyltransferase 2) using the numbering given in entry NP_006700.2 (GeneID 10919).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-G9A/EHMT2 (IHC)"
Write a review
or to review a product.
Viewed