Anti-PPP1CC (IHC)

Anti-PPP1CC (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00485-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00485 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Protein phosphatase that associates with over 200 regulatory proteins to form... more
Product information "Anti-PPP1CC (IHC)"
Protein function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). [The UniProt Consortium]
Keywords: Anti-PP-1G, Anti-PPP1CC, EC=3.1.3.16, Anti-Protein phosphatase 1C catalytic subunit, Anti-Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00485

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, X. laevis, X. tropicalis, bovine, dog, horse, guinea pig_10141, pig, panda, monkey, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00485 maps to a region between residue 280 and the C-terminus (residue 323) of human Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform using the numbering given in entry NP_002701.1 (GeneID 5501).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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