Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00461-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00461 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds... more
Product information "Anti-RAP80 (IHC)"
Protein function: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. [The UniProt Consortium]
Keywords: | Anti-UIMC1, Anti-RAP80, Anti-BRCA1-A complex subunit RAP80, Anti-Receptor-associated protein 80, Anti-Retinoid X receptor-interacting protein 110, Anti-Ubiquitin interaction motif-containing protein 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00461 |
Properties
Application: | IHC, IHC-IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: gorilla) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00461 maps to a region between residue 650 and the C-terminus (residue 719) of human Receptor Associated Protein 80 using the numbering given in entry NP_057374.3 (GeneID 51720). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K20775 | Matching products |
UniProt ID : | Q96RL1 | Matching products |
Gene ID | GeneID 51720 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed