Anti-RAP80 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00461-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00461 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds... more
Product information "Anti-RAP80 (IHC)"
Protein function: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. [The UniProt Consortium]
Keywords: Anti-UIMC1, Anti-RAP80, Anti-BRCA1-A complex subunit RAP80, Anti-Receptor-associated protein 80, Anti-Retinoid X receptor-interacting protein 110, Anti-Ubiquitin interaction motif-containing protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00461

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: gorilla)
Immunogen: synthetic peptide. The epitope recognized by IHC-00461 maps to a region between residue 650 and the C-terminus (residue 719) of human Receptor Associated Protein 80 using the numbering given in entry NP_057374.3 (GeneID 51720).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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