Anti-TORC1 (IHC)

Anti-TORC1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00452-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00452 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Transcriptional coactivator for CREB1 which activates transcription through... more
Product information "Anti-TORC1 (IHC)"
Protein function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [The UniProt Consortium]
Keywords: Anti-TORC-1, Anti-Transducer of CREB protein 1, Anti-CREB-regulated transcription coactivator 1, Anti-Mucoepidermoid carcinoma translocated protein 1, Anti-Transducer of regulated cAMP response element-binding protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00452

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, zebrafish, dog, horse, guinea pig_10141, panda, orangutan, monkey, gorilla, chimpanzee, nile tilapia, tasmanian devil)
Immunogen: synthetic peptide. The epitope recognized by IHC-00452 maps to a region between residue 600 and the C-terminus (residue 634) of human Transducer of Regulated cAMP Response element-binding protein 1 using the numbering given in entry NP_056136.1 (GeneID 23373 ).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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