Anti-HDAC3 (IHC)

Anti-HDAC3 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00428-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00428 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... more
Product information "Anti-HDAC3 (IHC)"
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). [The UniProt Consortium]
Keywords: Anti-HD3, Anti-HDAC3, Anti-SMAP45, Anti-RPD3-2, EC=3.5.1.98, Anti-Histone deacetylase 3
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00428

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by IHC-00428 maps to a region between residue 375 and the C-terminus (residue 428) of human Histone Deacetylase 3 using the numbering given in Swiss-Prot entry O15379 (GeneID 8841).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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