Anti-RAP1 (IHC)

Anti-RAP1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00426-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00426 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Acts both as a regulator of telomere function and as a transcription regulator.... more
Product information "Anti-RAP1 (IHC)"
Protein function: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. [The UniProt Consortium]
Keywords: Anti-hRap1, Anti-DRIP5, Anti-PP8000, Anti-TERF2IP, Anti-RAP1 homolog, Anti-TRF2-interacting telomeric protein 1, Anti-Repressor/activator protein 1 homolog, Anti-TERF2-interacting telomeric protein 1, Anti-Dopamine receptor-interacting protein 5
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00426

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide. Antibody was generated using recombinant full length human RAP1 (Telomeric repeat binding factor 2 interacting protein 1) according to entry NP_061848.2 (GeneID 54386).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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