Anti-Fen1 (IHC)

Anti-Fen1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00335-T 10 µl (5 µg) -

2 - 8 business days*

164.00€
IHC-00335 100 µl (50 µg) -

2 - 8 business days*

623.00€
 
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease... more
Product information "Anti-Fen1 (IHC)"
Protein function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. [The UniProt Consortium]
Keywords: Anti-MF1, Anti-RAD2, Anti-FEN-1, Anti-hFEN-1, Anti-DNase IV, Anti-Maturation factor 1, Anti-Flap endonuclease 1, Anti-Flap structure-specific endonuclease 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00335

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: sheep, bovine, horse, pig, panda, orangutan, gorilla, chimpanzee, northern white-cheeked gibbon, little brown bat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00335 maps to a region between residues 250 and 300 of human Flap Structure Endonuclease 1 using the numbering given in entry NP_004102.1 (GeneID 2237).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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