Anti-NBS1 IHC Antibody, affinity purifie (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00258-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00258 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in... more
Product information "Anti-NBS1 IHC Antibody, affinity purifie (IHC)"
Protein function: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. [The UniProt Consortium]
Keywords: Anti-NBS, Anti-NBN, Anti-Nibrin, Anti-Cell cycle regulatory protein p95, Anti-Nijmegen breakage syndrome protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00258

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, francois's leaf monkey, angolan talapoin)
Immunogen: synthetic peptide. The epitope recognized byIHC-00258 maps to a region between residue 704 and 754 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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