Anti-PALB2 IHC Antibody, affinity purifie (IHC)

Anti-PALB2 IHC Antibody, affinity purifie (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00251-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00251 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Plays a critical role in homologous recombination repair (HRR) through its... more
Product information "Anti-PALB2 IHC Antibody, affinity purifie (IHC)"
Protein function: Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. [The UniProt Consortium]
Keywords: Anti-FANCN, Anti-PALB2, Anti-Partner and localizer of BRCA2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00251

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, monkey, gorilla, chimpanzee, northern white-cheeked gibbon, crab-eating macaque)
Immunogen: synthetic peptide. The epitope recognized by IHC-00251 maps to a region between residue 200 and 250 of human partner and localizer of BRCA2 using the numbering given in entry NP_078951.2 (GeneID 79728).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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