Anti-CHD8 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00246-T	10 µl (500 ng)		-		2 - 8 business days*		164.00€
IHC-00246	100 µl (5 µg)		-		2 - 8 business days*		623.00€

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Protein function: DNA helicase that acts as a chromatin remodeling factor and regulates... more

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Product information "Anti-CHD8 (IHC)"

Protein function: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. [The UniProt Consortium]

Keywords:	Anti-CHD-8, Anti-HELSNF1, Anti-ATP-dependent helicase CHD8, Anti-Helicase with SNF2 domain 1, Anti-Chromodomain-helicase-DNA-binding protein 8
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00246

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, bovine, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee, naked mole rat)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00246 maps to a region between residue 2252 and 2302 of human chromodomain helicase DNA binding protein 8 using the numbering given in entry NP_065971.2 (GeneID 57680).
Format:	Antigen Affinity Purified