Anti-RBM25/RED120 (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00233-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00233 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.... more
Product information "Anti-RBM25/RED120 (IHC)"
Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. [The UniProt Consortium]
Keywords: Anti-RBM25, Anti-RNPC7, Anti-RED120, Anti-Protein S164, Anti-RNA-binding protein 25, Anti-RNA-binding motif protein 25, Anti-Arg/Glu/Asp-rich protein of 120 kDa, Anti-RNA-binding region-containing protein 7
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00233

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00233 maps to a region between residue 475 and 525 of human RNA binding motif protein 25 (Arg/Glu/Asp-rich protein, 120 kDa) using the numbering given in entry AAF19255.1 (GeneID 58517).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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