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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00233-T | 10 µl (1 µg) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00233 | 100 µl (10 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.... more
Product information "Anti-RBM25/RED120 (IHC)"
Protein function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. [The UniProt Consortium]
Keywords: | Anti-RBM25, Anti-RNPC7, Anti-RED120, Anti-Protein S164, Anti-RNA-binding protein 25, Anti-RNA-binding motif protein 25, Anti-Arg/Glu/Asp-rich protein of 120 kDa, Anti-RNA-binding region-containing protein 7 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00233 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, monkey, gorilla, chimpanzee) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00233 maps to a region between residue 475 and 525 of human RNA binding motif protein 25 (Arg/Glu/Asp-rich protein, 120 kDa) using the numbering given in entry AAF19255.1 (GeneID 58517). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K12822 | Matching products |
UniProt ID : | P49756 | Matching products |
Gene ID | GeneID 58517 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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