Anti-CPSF73 (IHC)

Anti-CPSF73 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00229-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00229 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex... more
Product information "Anti-CPSF73 (IHC)"
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. [The UniProt Consortium]
Keywords: Anti-CPSF3, Anti-CPSF73, Anti-CPSF 73 kDa subunit, Anti-mRNA 3'-end-processing endonuclease CPSF-73, Anti-Cleavage and polyadenylation specificity factor subunit 3, Anti-Cleavage and polyadenylation specificity factor 73 kDa subunit
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00229

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: bovine, dog, horse, rabbit, panda, orangutan, monkey, gorilla, chimpanzee, small-eared galago, hirteen-lined ground squirrel)
Immunogen: synthetic peptide. The epitope recognized by IHC-00229 maps to a region between residue 634 and 684 of human cleavage and polyadenylation specific factor 3, 73kDa using the numbering given in entry NP_057291.1 (GeneID 51692).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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