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Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00229-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00229 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex... more
Product information "Anti-CPSF73 (IHC)"
Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. [The UniProt Consortium]
Keywords: | Anti-CPSF3, Anti-CPSF73, Anti-CPSF 73 kDa subunit, Anti-mRNA 3'-end-processing endonuclease CPSF-73, Anti-Cleavage and polyadenylation specificity factor subunit 3, Anti-Cleavage and polyadenylation specificity factor 73 kDa subunit |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00229 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: bovine, dog, horse, rabbit, panda, orangutan, monkey, gorilla, chimpanzee, small-eared galago, hirteen-lined ground squirrel) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00229 maps to a region between residue 634 and 684 of human cleavage and polyadenylation specific factor 3, 73kDa using the numbering given in entry NP_057291.1 (GeneID 51692). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K14403 | Matching products |
UniProt ID : | Q9UKF6 | Matching products |
Gene ID | GeneID 51692 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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