Anti-SMARCB1/SNF5 (IHC)

Anti-SMARCB1/SNF5 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00228-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00228 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Core component of the BAF (hSWI/SNF) complex. This ATP- dependent... more
Product information "Anti-SMARCB1/SNF5 (IHC)"
Protein function: Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. [The UniProt Consortium]
Keywords: Anti-hSNF5, Anti-BAF47, Anti-SMARCB1, Anti-SNF5 homolog, Anti-BRG1-associated factor 47, Anti-Integrase interactor 1 protein, Anti-SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00228

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, X. laevis, X. tropicalis, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey)
Immunogen: synthetic peptide. The epitope recognized by IHC-00228 maps to a region between residue 75 and 125 of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (sucrose nonfermenting 5) using the numbering given in entry NP_0030
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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