Anti-phospho-PCNA (Tyr211) (IHC)

Anti-phospho-PCNA (Tyr211) (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00219-T 10 µl (500 ng) -

2 - 8 business days*

164.00€
IHC-00219 100 µl (5 µg) -

2 - 8 business days*

665.00€
 
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of... more
Product information "Anti-phospho-PCNA (Tyr211) (IHC)"
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [The UniProt Consortium]
Keywords: Anti-phospho-PCNA, Anti-phospho-Cyclin, Anti-phospho-Proliferating cell nuclear antigen
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00219

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide. Immunogen for IHC-00219 was a phosphorylated synthetic peptide, which represented a portion of human proliferating cell nuclear antigen (GeneID 5111) around tyrosine 211 according to the numbering given inentry NP_002583.1.
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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