Anti-AKAP8/AKAP95 (IHC)

Anti-AKAP8/AKAP95 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00217-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00217 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Anchoring protein that mediates the subcellular compartmentation of... more
Product information "Anti-AKAP8/AKAP95 (IHC)"
Protein function: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation, the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation, the function probably implicates targeting of PKA to NFKB1. [The UniProt Consortium]
Keywords: Anti-AKAP8, Anti-AKAP95, Anti-AKAP-8, Anti-AKAP 95, Anti-A-kinase anchor protein 8, Anti-A-kinase anchor protein 95 kDa
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00217

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: bovine, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00217 maps to a region between residue 642 and the C-terminus (residue 692) of human A-kinase anchor protein 8 using the numbering given in entry NP_005849.1 (GeneID 10270).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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