Anti-TRIM33/TIF1gamma (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00216-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00216 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear... more
Product information "Anti-TRIM33/TIF1gamma (IHC)"
Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). [The UniProt Consortium]
Keywords: Anti-TRIM33, Anti-KIAA1113, Anti-TIF1-gamma, EC=6.3.2.-, Anti-Protein Rfg7, Anti-Ectodermin homolog, Anti-RET-fused gene 7 protein, Anti-E3 ubiquitin-protein ligase TRIM33, Anti-Tripartite motif-containing protein 33
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00216

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, X. tropicalis, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla)
Immunogen: synthetic peptide. The epitope recognized by IHC-00216 maps to a region between residue 1077 and the C-terminus (residue 1127) of human tripartite motif-containing 33 (transcriptional intermediary factor 1 gamma) using the numbering given in entry NP_056990.3 (GeneID 51592)
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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