Anti-ACINUS/ACN1 (IHC)

Anti-ACINUS/ACN1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00215-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00215 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Auxiliary component of the splicing-dependent multiprotein exon junction... more
Product information "Anti-ACINUS/ACN1 (IHC)"
Protein function: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets, ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. [The UniProt Consortium]
Keywords: Anti-ACIN1, Anti-Acinus, Anti-ACINUS, Anti-Apoptotic chromatin condensation inducer in the nucleus
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00215

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat, X. laevis, X. tropicalis, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla)
Immunogen: synthetic peptide. The epitope recognized by IHC-00215 maps to a region between residue 1291 and the C-terminus (residue 1341) of human apoptotic chromatin condensation inducer 1 using the numbering given in entry NP_055792.1 (GeneID 22985).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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