Anti-SMARCC2/BAF170 (IHC)

Anti-SMARCC2/BAF170 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00213-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00213 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Involved in transcriptional activation and repression of select genes by... more
Product information "Anti-SMARCC2/BAF170 (IHC)"
Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [The UniProt Consortium]
Keywords: Anti-BAF170, Anti-SMARCC2, Anti-BRG1-associated factor 170, Anti-SWI/SNF complex 170 kDa subunit, Anti-SWI/SNF complex subunit SMARCC2, Anti-SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00213

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, dog, horse, rabbit, pig, panda, orangutan, monkey, gorilla, chimpanzee, chinese hamster, naked mole rat)
Immunogen: synthetic peptide. The epitope recognized by IHC-00213 maps to a region between residue 1164 and the C-terminus (residue 1214) of human, SMARCC2/BAF170 using the numbering given in entry NP_003066.2 (GeneID 6601).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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