Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00211-T | 10 µl (1 µg) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00211 | 100 µl (10 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Transcription elongation factor which binds histone H3 and plays a key role in... more
Product information "Anti-SUPT6H (IHC)"
Protein function: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. [The UniProt Consortium]
Keywords: | Anti-hSPT6, Anti-SUPT6H, Anti-KIAA0162, Anti-Tat-CT2 protein, Anti-Tat-cotransactivator 2 protein, Anti-Histone chaperone suppressor of Ty6, Anti-Transcription elongation factor SPT6 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00211 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00211 maps to a region between residues 425 and 475 of human Suppressor of Ty 6 Homolog using the numbering given in entry NP_003161.2 (GeneID 6830). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K11292 | Matching products |
UniProt ID : | Q7KZ85 | Matching products |
Gene ID | GeneID 6830 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed