Anti-SUPT5H (IHC)

Anti-SUPT5H (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00210-T 10 µl (2500 ng) -

2 - 8 business days*

164.00€
IHC-00210 100 µl (25 µg) -

2 - 8 business days*

623.00€
 
Protein function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which... more
Product information "Anti-SUPT5H (IHC)"
Protein function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. [The UniProt Consortium]
Keywords: Anti-SPT5, Anti-hSPT5, Anti-SUPT5H, Anti-DSIF p160, Anti-Tat-CT1 protein, Anti-DSIF large subunit, Anti-Tat-cotransactivator 1 protein, Anti-Transcription elongation factor SPT5, Anti-DRB sensitivity-inducing factor large subunit
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00210

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, chicken, turkey, bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, monkey, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by IHC-00210 maps to a region between residues 1040 and the C-terminus (residue 1087) of human Suppressor of Ty 5 Homolog using the numbering given in entry NP_003160.2 (GeneID 6829).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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